Flagship Pioneering has patented a method for altering plant genomes using RNA-guided nucleases. The method involves delivering a ribonucleoprotein composition into plant protoplasts to modify target nucleotide sequences through specific thermal treatment. GlobalData’s report on Flagship Pioneering gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Flagship Pioneering, Cancer treatment biomarkers was a key innovation area identified from patents. Flagship Pioneering's grant share as of January 2024 was 10%. Grant share is based on the ratio of number of grants to total number of patents.
Genome editing in plant cells using rna-guided nuclease
A recently granted patent (Publication Number: US11859219B1) discloses a method for altering a target nucleotide sequence in a population of protoplasts of a plant. The method involves delivering a preassembled ribonucleoprotein composition containing an RNA-guided nuclease protein and a guide RNA designed to modify the target nucleotide sequence. The delivery process includes contacting the protoplast population with the composition and incubating them at 37 degrees Celsius for a specific duration, resulting in the alteration of the target nucleotide sequence. Additionally, the method allows for further incubation at a temperature conducive to plant growth post the initial alteration process.
The patent also details various aspects of the method, including the selection of RNA-guided nucleases, the source of protoplasts from different plant tissues or plant types, and the different treatments that can be applied during the delivery process. Furthermore, the composition may include chemical or physical agents to enhance the alteration process, and peptides or carrier molecules can be included in the composition for effective delivery. The method also encompasses the growth or regeneration of plants from the altered protoplasts, chromosome doubling in haploid protoplasts, and the detection of the altered target nucleotide sequence in the protoplast population. Specific examples of target genes and guide RNA sequences are provided in the claims, showcasing the versatility and applicability of the method across different plant species.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.
